Reduced Global Cerebral Oxygen Metabolic Rate in Sickle Cell Disease A…
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작성자 Lyda 작성일 25-09-02 04:50 조회 3 댓글 0본문
Anemia is the most typical blood disorder in the world. In patients with chronic anemia, reminiscent of sickle cell disease or main thalassemia, cerebral blood circulate will increase to compensate for decreased oxygen content material. However, the consequences of chronic anemia on oxygen extraction fraction (OEF) and cerebral metabolic fee of oxygen (CMRO2 ) are much less well understood. In this research, we examined 47 sickle-cell anemia subjects (age 21.7 ± 7.1, female 45%), 27 non-sickle anemic topics (age 25.Zero ± 10.4, female 52%) and 44 wholesome controls (age 26.Four ± 10.6, female 71%) using MRI metrics of brain oxygenation and flow. Phase contrast MRI was used to measure resting cerebral blood circulation, while T2 -relaxation-beneath-spin-tagging (Trust) MRI with illness appropriate calibrations were used to measure OEF and CMRO2 . We noticed that patients with sickle cell illness and different chronic anemias have decreased OEF and CMRO2 (respectively 27.4 ± 4.1% and 3.39 ± 0.71 ml O2 /100 g/min in sickle cell disease, 30.8 ± 5.2% and BloodVitals review 3.Fifty three ± 0.Sixty four ml O2 /100 g/min in different anemias) in comparison with controls (36.7 ± 6.0% and 4.00 ± 0.65 ml O2 /100 g/min). Impaired CMRO2 was proportional to the diploma of anemia severity. We additional demonstrate striking concordance of the current work with pooled historical knowledge from patients having broad etiologies for their anemia. The diminished cerebral oxygen extraction and metabolism are in line with emerging knowledge demonstrating increased non-nutritive movement, or physiological shunting, in sickle cell illness patients.
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