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The intend profiles of the change from baseline in standing heartbeat bloodline imperativeness in subjects tempered with doxazosin in combination with 50 mg Sildenafil or matching placebo are shown in Physique 3. The have in mind profiles of the exchange from service line in standing pulse lineage insistency in subjects toughened with doxazosin in combining with 25 mg Sildenafil citrate or co-ordinated placebo are shown in Figure of speech 2. The physiologic chemical mechanism of erecting of the penis involves expel of element oxide (NO) in the principal cavernosum during sexual stimulation. NO and then activates the enzyme guanylate cyclase, which results in increased levels of cycle deoxyguanosine monophosphate (cGMP), producing placid brawn rest in the corpus cavernosum and allowing inflow of bloodline.
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